Dr. Eva Feldman to present new data on ALS trial
Dr. Eva Feldman, director of the Taubman Institute, will present new data Oct. 8 on the Phase I trial she leads that involves implanting stem cells into the spinal cords of patients with ALS.
Dr. Feldman will present the interim data in her role as president of the American Neurological Association (ANA) at the ANA's annual conference in Boston.
The Phase I trial, being conducted in conjunction with Emory University and the biomedical firm Neuralstem, was designed to assess the safety of spinal cord neural stem cells and the intraspinal transplantation method in ALS patients. It commenced in January 2010, and consisted of 18 treatments in 15 patients. The trial was designed to follow a risk escalation paradigm. The first 12 patients were each transplanted in the lumbar (lower back) region of the spine, beginning with non-ambulatory and advancing to ambulatory cohorts.
The trial then advanced to transplantation in the cervical (upper) region of the spine. The first cohort of three was treated in the cervical region only. In an amendment to the trial design, The Food and Drug Administration (FDA) approved the return of previously-treated patients to this cohort. Consequently, the last cohort of three patients received injections in the cervical region in addition to the lumbar injections they had received earlier. All injections delivered 100,000 cells, for a dosing range of up to 1.5 million cells. The last patient was treated in August, 2012. None of the patients have suffered significant adverse effects as a result of the stem cell implantation.
ALS patient feels great after stem cell transplant
Took part in Phase I of Dr. Eva Feldman's human clinical trial
Ted Harada tells Crain's Detroit Business that nearly nine months after receiving stem cell injections to his spinal cord, improvement persists.
The birth of two human clinical trials
The Taubman Institute’s overriding purpose is to discover potential new treatments that can be tested in clinical trials. Watch as two Taubman Scholars explain how they made it happen.
Institute training video helps physicians overseas
U-M exam method for diabetic nerve damage translated to Mandarin Chinese. The Taubman institute has produced video of an exam protocol that will help doctors in Asia and elsewhere as they grapple with growing diabetes epidemics and the resulting complications.
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Taubman Scholars direct 31 human clinical trials
Science funded by the Taubman Institute has led to 31 current human clinical trials, studying potential therapies for diseases including breast cancer, muscular dystrophy, diabetes and ALS. See the complete list of trials.
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Leaders of state and local government visited the Taubman Institute on March 18 to tour Taubman Scholar labs and discuss the potential medical research offers for both improving the health of residents and establishing new jobs and businesses in Michigan.