A new drug to treat diabetic kidney disease? Taubman Scholar Dr. Frank Brosius partners in clincial trial
With almost 2 million new cases diagnosed each year, more than 8% of the U.S. population has diabetes. And roughly 30% will eventually develop diabetic kidney disease.
Researchers at the University of Michigan Medical School are partnering with Eli Lilly and Company in using a human genome-wide data set, together with mouse models, to identify a key driver of diabetic kidney disease.
Sponsored by Lilly, a new clinical study will examine whether a drug being developed to treat arthritis and skin diseases can be repurposed to help prevent progression of diabetic kidney disease. It takes advantage of genome-wide expression data analyzed by Matthias Kretzler, M.D., Frank Brosius, M.D. and their teams, as well as the investigators’ expertise in animal models of diabetic complications.
"We prioritized this pathway as the most relevant in diabetic nephropathy," said Kretzler. "Together with data from model systems published, there was such strong evidence that Lilly repurposed their compound and started a phase II trial in less than 15 months. It’s exciting because this kind of collaboration between industry and academia is exactly the way we can accelerate new therapies to help patients."
Kretzler is widely recognized for international multicenter studies of genome-wide expression profiles of major diseases affecting human kidneys including diabetes, hypertension and autoimmune diseases like lupus.
"Dr. Kretzler put together a network of research teams to establish a worldwide human genome-wide renal gene expression consortium,” noted Brosius, whose lab is one of 12 organizations participating in the NIH-sponsored Animal Models of Diabetic Complications Consortium. "Then my group provided the animal model studies and the in-depth understanding of diabetic complications that allowed us to focus on the pathway. This highly collaborative approach makes the U-M one of the only places in the world with the combined expertise to move this project forward."
New Taubman Prize trophy debuts
The new trophy for the Taubman Prize for Excellence in Translational Medical Research, which was designed in consultation with institute founder Mr. A. Alfred Taubman, was presented at the institute's Oct. 11 symposium. The modern sculpture was created using a novel 3D printing technique.
Call for applications
Taubman Institute to offer six new scholar grants
The institute is accepting applications through Dec. 1 for its flagshop Taubman Scholar grant program, which is open to clinician-scientists on the U-M Medical School Faculty. Grants are $150,000 per year for three years.
Click here for details
U-M offers new early detection prostate cancer test
Research by Taubman Scholar Dr. Arul Chinnaiyan has let to the development of a new test for prostate cancer that is far more accurate than the standard PSA test, the University of Michigan has announced.
Click here to read more.
news & events
Is there a link between tonsils and psoriasis?
Trial tested the effect of tonsillectomy on the skin disease
Taubman Emerging Scholar Dr. Johann Gudjonsson and colleagues found that people who had their tonsils removed showed improvment.
Click here to read the entire story
Fall Visiting Professor Lectures schedule
Distinguished guest speakers include experts in lung, muscle and nerve diseases
Click here for the lineup
Breast cancer clinical trial enrolling patients
Research by Taubman Scholar Dr. Max Wicha into breast cancer stem cells is the basis for a new human clinical trial of the drug Reparixin, which scientists hope will curb the growth of the tumor-fueling cells.