Sung Won Choi, M.D.
Sung Won Choi, M.D.
Assistant Professor of Pediatrics and Communicable Diseases
Edith Briskin/SKS Foundation Emerging Scholar
Improving the Success of Bone Marrow Transplants
During the past 40 years, bone marrow transplantation has been used with increasing frequency to treat numerous malignant and nonmalignant diseases. The procedure replaces damaged or destroyed bone marrow — soft tissue inside bones that helps form blood cells, including white cells, that are responsible for the immune response — with healthy bone marrow stem cells.
As with any transplant into the human body, the procedure’s success is threatened by graft-versus-host disease (GVHD) — the major complication of bone marrow transplantation in which the newly transplanted material attacks the transplant recipient’s body.
Dr. Sung Won Choi is studying how to better prevent and treat acute GVHD, and currently is investigating the role of histone deacetylase inhibition in GVHD prevention and translating exciting laboratory insights into a novel, proof-in-principal clinical trial.
A member of the Blood and Marrow Transplantation Program at the U-M, she is working to lower rates of GVHD, which can vary from 30-40 percent among related donors, to 60-80 percent between unrelated donors and recipients. If GVHD progresses in a patient, the transplant can fail.
Dr. Sung Choi received a B.S. from the University of Michigan and her M.D. from Wayne State University. She completed her pediatric residency at New York University and fellowship training in pediatric hematology-oncology at Michigan. She then joined the Department of Pediatrics and Communicable Diseases in 2006.
Visiting Professor lecture to feature genetics expert
Brendan Lee, M.D., Ph.D., a genetics expert from Baylor College of Medicine, will headline the Pediatrics Research Symposium Oct. 6 at the U-M Medical School.
Click here for details and registration information.
New U-M President visits Taubman Institute
The Institute hosted a fellow clinician-scientist when the University of Michigan’s new president paid a visit to the A. Alfred Taubman Biomedical Science Research Building.
People who care
Institute welcomes new gift officer
Maria Muller has been appointed to work with connect donors with funding opportunities at the Taubman Institute.
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news & events
Institute symposium set for Oct. 10
The A. Alfred Taubman Medical Research Institute will award the 2014 $100,000 Taubman Prize for Excellence in Translational Medical Science at its 7th annual symposium at 10 a.m. on Oct. 10.
Dr. Carl June, a physician-scientist who developed a personalized immunotherapy for leukemia using patients’ own T cells, will receive the honor and deliver the symposium's keynote address.
Click here for symposium details.
Drug cuts risk of bone-marrow transplant side effect
Taubman Emerging Scholar Sung Won Choi, M.D., is the lead author of a new study that finds a new way to help prevent graft-vs-host disease in cancer patients receiving bone-marrow transplants.
Study: Two types of cancer stem cells lead to metastasis
Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to a new study published by Taubman Senior Scholar Dr. Max Wicha.